Description

4-(Hydroxymethyl)-D-Phenylalanine is a non-natural, chiral amino acid derivative of significant interest in advanced pharmaceutical synthesis and peptide research. Its unique structure, featuring a hydroxymethyl side chain on the aromatic ring, makes it a valuable building block for introducing specific functional groups and modulating the properties of bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used as a modified amino acid residue in Solid-Phase Peptide Synthesis (SPPS) to incorporate hydroxymethyl functionality into peptide chains.
• Proteomics & Biochemical Research: Serves as a specialty reagent for studying protein structure-function relationships and designing peptide probes.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks.
• Diagnostic Agent Precursor: Acts as a starting material for synthesizing radiolabeled compounds or contrast agents used in medical imaging.

Basic Information

Product Name	4-(Hydroxymethyl)-D-Phenylalanine
CAS No.	15720-17-9
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	D-4-(Hydroxymethyl)phenylalanine; (R)-2-Amino-3-[4-(hydroxymethyl)phenyl]propanoic acid; H-D-4-Hmp-OH; D-p-Hydroxymethylphenylalanine; 4-Hydroxymethyl-D-Phe; D-4-Carbinoylphenylalanine; D-4-Hydroxymethylphenylalanine; Fmoc-D-4-(hydroxymethyl)Phe-OH (protected form)
EINECS	Contact for details

Quality Control

We supply 4-(Hydroxymethyl)-D-Phenylalanine in high-purity grades suitable for research and cGMP manufacturing. Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.