Description

7-Cyano-7-Deaza-2'-Deoxyadenosine is a chemically modified nucleoside analog, serving as a critical building block in advanced nucleic acid research and development. Its unique 7-deaza-7-cyano structure provides enhanced stability and specific base-pairing properties, making it invaluable for creating modified oligonucleotides. This compound is primarily utilized by research institutions and biotechnology companies engaged in antisense therapy development, diagnostic probe design, and fundamental studies of nucleic acid structure and function.

Application

• Antisense Oligonucleotide Synthesis: A key monomer for constructing oligonucleotides with increased nuclease resistance and binding affinity for therapeutic and research applications.
• Diagnostic Probe Development: Used in the design of fluorescent probes and molecular beacons for sensitive detection of DNA and RNA sequences in diagnostic assays.
• Structural Biology Studies: Incorporated into oligonucleotides to investigate nucleic acid duplex stability, triplex formation, and protein-nucleic acid interactions.
• SELEX (Systematic Evolution of Ligands by Exponential Enrichment): Employed to expand the chemical diversity of nucleic acid libraries for aptamer selection against challenging targets.
• Synthetic Biology: Serves as a modified base for creating artificial genetic systems and xenonucleic acids (XNAs) with novel properties.
• Pharmaceutical Intermediate: Acts as a precursor in the synthesis of more complex nucleoside-based pharmaceutical compounds.

Basic Information

Item	Details
Product Name	7-Cyano-7-Deaza-2'-Deoxyadenosine
CAS No.	15676-19-4
Molecular Formula	C11H11N5O3
Molecular Weight	261.24 g/mol
Synonyms	7-Cyano-7-deaza-2'-deoxyadenosine; 7-Deaza-7-cyano-2'-deoxyadenosine; 4-Amino-7-cyano-7-deaza-2'-deoxyadenosine; 7-CN-7-deaza-dA; Tubercidin-7-carbonitrile, 2'-deoxy-; 2'-Deoxy-7-cyano-7-deazadenosine; 7-Cyano-7-deaza-dA; 7-CN-7-deaza-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our 7-Cyano-7-Deaza-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.