Description

L-(+)-n-[p-[[(2-Amino-7,8-Dihydro-4-Hydroxy-6-Pteridinyl)Methyl]Nitrosamino]Benzoyl]-Glutamic Acid CAS NO 15574-33-1 is a specialized folate analog and a key intermediate in advanced biochemical research and pharmaceutical synthesis. This compound is valued for its precise molecular structure, which is critical for investigating folate metabolism pathways and developing targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, metabolic disorder research, and the development of novel enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antifolate drugs and targeted cancer therapeutics.
• Biochemical Research: Used as a reference standard and tool compound in studies of dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Metabolic Pathway Analysis: Employed in research to elucidate and inhibit specific steps in cellular folate metabolism.
• Academic & Discovery Research: Serves as a high-purity chemical for universities and R&D labs exploring new mechanisms in cell biology and medicinal chemistry.
• Analytical Standard: Used for method development, calibration, and quality control in HPLC and LC-MS analysis within pharmaceutical quality assurance.

Basic Information

Product Name	L-(+)-n-[p-[[(2-Amino-7,8-Dihydro-4-Hydroxy-6-Pteridinyl)Methyl]Nitrosamino]Benzoyl]-Glutamic Acid
CAS No.	15574-33-1
Molecular Formula	C19H20N8O7
Molecular Weight	472.41 g/mol
Synonyms	N-[4-[[(2-Amino-4-hydroxy-7,8-dihydro-6-pteridinyl)methyl]nitrosoamino]benzoyl]-L-glutamic acid; L-N-[p-[[(2-Amino-4-hydroxy-7,8-dihydro-6-pteridinyl)methyl]nitrosamino]benzoyl]glutamic acid; 4-Nitroso-4-deaminopteroic acid; Aminopterin N-oxide analog; Folate antagonist intermediate; NSC 139490; PT523 derivative
EINECS	Contact for details

Quality Control

Our L-(+)-n-[p-[[(2-Amino-7,8-Dihydro-4-Hydroxy-6-Pteridinyl)Methyl]Nitrosamino]Benzoyl]-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.