Description

n-Acetylphenylalanylpuromycin is a chemically modified derivative of the classic protein synthesis inhibitor puromycin. This compound is a critical biochemical tool for researchers studying ribosome function, translation termination, and antibiotic mechanisms. It is primarily utilized in life science research and pharmaceutical development, particularly in the fields of molecular biology, biochemistry, and antibiotic discovery.

Application

• Biochemical Research: A key reagent for investigating the molecular mechanisms of protein synthesis and ribosome function.
• Antibiotic Mechanism Studies: Used as a structural analog to study the action and resistance pathways of puromycin and related aminonucleoside antibiotics.
• Enzyme Substrate: Acts as a substrate for specific peptidyl transferase activity assays in ribosome profiling experiments.
• Cell Biology: Employed in studies of translation inhibition and its effects on cellular processes and viability.
• Pharmaceutical Development: Serves as a reference compound and intermediate in the research and development of novel antimicrobial agents.

Basic Information

Product Name	n-Acetylphenylalanylpuromycin
CAS No.	15545-21-8
Molecular Formula	C28H37N7O8
Molecular Weight	599.64 g/mol
Synonyms	N-Acetyl-L-phenylalanylpuromycin; Ac-Phe-Pur; N-Acetylphenylalanylpuromycin; Puromycin, N-acetyl-L-phenylalanyl-; N-Acetylphenylalanyl-puronycin; L-Phenylalanine, N-acetyl-, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-(3-((2S,3S,4R,5R)-5-(dimethylamino)-3,4-dihydroxyoxolan-2-yl)-3-hydroxy-2-(4-methoxyphenyl)-1-oxopropyl)-2,3,4,6-tetradeoxy-α-D-threo-hexopyranosid-4-yl)amide; Ac-Phe-PMN
EINECS	Contact for details

Quality Control

Our n-Acetylphenylalanylpuromycin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.