Description

Histidine Dihydrochloride is the dihydrochloride salt form of the essential amino acid L-Histidine, a critical building block for proteins and peptides. This compound is valued for its enhanced solubility and stability in aqueous formulations compared to the free base form. It serves as a vital raw material and intermediate in the pharmaceutical, nutraceutical, and biochemical research sectors, where precise quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediates: A key starting material in the synthesis of active pharmaceutical ingredients (APIs) and complex peptides.
• Cell Culture Media: An essential nutrient component in mammalian and microbial cell culture systems for biopharmaceutical production.
• Dietary Supplements & Clinical Nutrition: Used in parenteral nutrition solutions and specialized amino acid supplement formulations.
• Biochemical Research: Employed as a substrate or standard in enzymatic studies, metabolic research, and protein chemistry.
• Cosmetic & Personal Care: Incorporated into hair and skin care products for its purported moisturizing and conditioning properties.
• Food Fortification: Used to enhance the nutritional profile of specific food products and medical foods.

Basic Information

Product Name	Histidine Dihydrochloride
CAS No.	15474-90-5
Molecular Formula	C6H11N3O2 • 2HCl
Molecular Weight	228.10 g/mol
Synonyms	L-Histidine Dihydrochloride; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid dihydrochloride; Histidine HCl; Histidine Hydrochloride; Histidine Dihydrochloride Monohydrate (common hydrate form); Histidinium Chloride; H-His-OH•2HCl; Histidine Dihydrochloride Salt
EINECS	239-472-7

Quality Control

Our Histidine Dihydrochloride is manufactured under a strict quality management system. Each batch is tested to ensure it meets high-purity standards suitable for demanding applications. We can supply material compliant with various pharmacopeial monographs, including USP and EP, upon request. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent caking and degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	+8.5° to +10.5° (c=1 in H2O)
pH (5% solution)	2.0 - 3.5
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.