Description

Neamine Hydrochloride is a chemically modified derivative of the aminoglycoside antibiotic neomycin, specifically its core neamine structure. This compound serves as a crucial pharmaceutical intermediate and biochemical research tool, valued for its role in studying antibiotic mechanisms and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in antibiotic development and molecular biology studies.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel aminoglycoside antibiotics and their derivatives.
• Biochemical Research: Used as a standard or probe in studies investigating bacterial ribosome binding, antibiotic resistance mechanisms, and RNA recognition.
• Microbiology Studies: Employed in research to understand the structure-activity relationships (SAR) of aminoglycoside antibiotics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Enzyme Inhibition Studies: Investigated for its potential in modulating enzymatic activity relevant to infectious diseases.
• Academic & Industrial R&D: Fundamental material for discovery chemistry and medicinal chemistry programs targeting bacterial infections.

Basic Information

Product Name	Neamine Hydrochloride
CAS No.	15446-43-2
Molecular Formula	C12H26N4O4 • xHCl
Molecular Weight	290.36 g/mol (free base)
Synonyms	Neamine HCl; 2-Deoxystreptamine-neobiosamine Hydrochloride; O-2,6-Diamino-2,6-dideoxy-α-L-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine Hydrochloride; Neomycin A Hydrochloride; Neamine Monohydrochloride; Framycetinamine Hydrochloride
EINECS	Contact for details

Quality Control

Our Neamine Hydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR, and stringent limits for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.