Description

Cyclo(-Gly-His) CAS NO 15266-88-3 is a synthetic cyclic dipeptide composed of glycine and histidine residues. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a structural motif and potential biological activity modulator. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications in peptide chemistry, drug discovery, and as a reference standard.

Application

• Pharmaceutical Intermediates: Serves as a key building block or precursor in the synthesis of more complex therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a model compound to study cyclic peptide structures, stability, and receptor-ligand interactions.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in HPLC or LC-MS systems.
• Enzyme Inhibition Studies: Investigated for potential activity as an inhibitor or modulator in enzymatic assays due to the histidine moiety.
• Cosmetic Peptide Formulations: Explored for use in advanced skincare products for its potential bioactive properties.

Basic Information

Product Name	Cyclo(-Gly-His)
CAS No.	15266-88-3
Molecular Formula	C8H10N4O2
Molecular Weight	194.19 g/mol
Synonyms	Cyclo(glycyl-histidyl); Gly-His cyclic dipeptide; Cyclo(Gly-His); L-Histidylglycine anhydride; 3-(2-Amino-2-oxoethyl)-6-(aminomethyl)-2,5-piperazinedione; DKPs (Diketopiperazines) derivative; Cyclo(His-Gly); 2,5-Diketopiperazine-1-acetic acid, 3-(aminomethyl)-
EINECS	Contact for details

Quality Control

Our Cyclo(-Gly-His) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.