Description

L-Serine, [3-14 C] CAS NO 15199-49-2 is a carbon-14 labeled isotopologue of the essential amino acid L-serine, specifically radiolabeled at the 3-carbon position. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, enabling precise tracking of serine utilization in biological systems. It is primarily required by research institutions, pharmaceutical developers, and CROs (Contract Research Organizations) engaged in advanced life science research, drug discovery, and biochemical analysis.

Application

• Metabolic Flux Analysis: Tracing the incorporation of serine into phospholipids, nucleotides, and other biomolecules in cell culture and in vivo studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Radiolabeled studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of serine-based drug candidates.
• Biochemical Pathway Elucidation: Research into one-carbon metabolism, glycine synthesis, and the serine biosynthesis pathway in cancer and neurological disorders.
• Protein and Peptide Research: Used in the study of protein synthesis, folding, and post-translational modifications where serine plays a key role.
• Diagnostic Agent Development: Serving as a precursor for the synthesis of radiolabeled probes and imaging agents for positron emission tomography (PET) or other modalities.
• Nutritional and Biomedical Research: Investigating serine requirements, transport, and function in various disease models and physiological states.

Basic Information

Item	Detail
Product Name	L-Serine, [3-14 C]
CAS No.	15199-49-2
Molecular Formula	C314CH7NO3
Molecular Weight	~106.1 g/mol (exact mass depends on specific activity)
Synonyms	(2S)-2-Amino-3-([14C]carboxy)propanoic acid; L-3-([14C]Carboxy)alanine; L-Serine-3-14C; Serine (L-), [3-14C]; [3-14C]-L-Serine; L-[3-14C]Serine; Radiolabeled L-Serine; Carbon-14 Labeled Serine
EINECS	Contact for details

Quality Control

Every batch of L-Serine, [3-14 C] is produced and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our quality commitment includes rigorous analytical testing via HPLC, NMR, and mass spectrometry to confirm radiochemical purity (>97% typical) and chemical purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, purity, solvent composition, and analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Custom ranges available)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (Specified on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.