Description

n-Formyl-L-Histidine is a chemically modified derivative of the essential amino acid L-Histidine, where a formyl group is introduced to the amino terminus. This modification is critical for enhancing the molecule's stability and altering its reactivity profile, making it a valuable building block in advanced synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, biochemical research, and the development of novel therapeutic agents.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid derivative in solid-phase and solution-phase peptide synthesis, particularly for sequences requiring histidine residues.
• Biochemical Research: Used as a substrate or standard in enzymatic studies and metabolic pathway investigations related to histidine metabolism.
• Pharmaceutical Development: Employed in the research and development of peptide-based drugs and diagnostic agents.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Protecting Group Chemistry: The formyl group can act as a temporary protecting group for the α-amino function in multi-step organic syntheses.

Basic Information

Product Name	n-Formyl-L-Histidine
CAS No.	15191-21-6
Molecular Formula	C7H9N3O3
Molecular Weight	183.16 g/mol
Synonyms	N-Formyl-L-histidine; L-Histidine, N-formyl-; Formylhistidine; F-His-OH; (2S)-2-Formamido-3-(1H-imidazol-4-yl)propanoic acid; NSC 3349; N-Formylhistidine; Nα-Formyl-L-histidine
EINECS	Contact for details

Quality Control

Our n-Formyl-L-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	+39.0° to +43.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.