Description

2-Fluoro-4-Mercapto-Aniline is a multifunctional aromatic amine featuring both a fluorine substituent and a thiol group, making it a valuable and versatile building block in advanced organic synthesis. This compound is critical for introducing specific structural motifs that influence the electronic and binding properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the fluorine atom's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine and thiol groups contribute to enhanced biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a chelating agent or precursor for ligands in transition metal catalysis, useful in cross-coupling and other asymmetric synthesis reactions.
• Material Science Research: Building block for functionalized polymers, dyes, and advanced organic materials requiring specific optoelectronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and bioconjugation reagents, leveraging the reactive thiol group for site-specific labeling of proteins and other biomolecules.

Basic Information

Product Name	2-Fluoro-4-Mercapto-Aniline
CAS No.	15178-48-0
Molecular Formula	C6H6FNS
Molecular Weight	143.18 g/mol
Synonyms	2-Fluoro-4-aminobenzenethiol; 4-Amino-2-fluorobenzenethiol; 2-Fluoro-1-amino-4-mercaptobenzene; Benzenethiol, 4-amino-2-fluoro-; 4-Amino-2-fluorothiophenol; 2-Fluoro-p-phenylenediamine-4-thiol; 2-Fluoro-4-sulfanyl-aniline
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Mercapto-Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.