Description

1,3,5[10]-Estratrien-3-Ol-17-One 3-Glucuronide Sodium Salt is a high-purity conjugated metabolite of estrone, specifically the sodium salt of its 3-O-glucuronide derivative. This compound is a critical reference standard and intermediate in pharmaceutical research and diagnostic development, offering a defined and stable form for precise analytical work. It is essential for laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors focused on steroid hormone metabolism, assay calibration, and drug development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of estrone metabolites in drug development and bioanalytical studies.
• Clinical Diagnostics: Serves as a key calibrator and control in immunoassays and LC-MS/MS methods for measuring estrogen levels in patient serum or urine samples.
• Biochemical Research: Employed in studies of estrogen metabolism, conjugation pathways, and the function of UDP-glucuronosyltransferase (UGT) enzymes.
• Metabolite Synthesis: Acts as a purified intermediate for the synthesis of other labeled or conjugated steroid metabolites for research purposes.
• Quality Control: Utilized in the quality assurance processes of pharmaceutical manufacturers producing hormone-based therapies.

Basic Information

Product Name	1,3,5[10]-Estratrien-3-Ol-17-One 3-Glucuronide Sodium Salt
CAS No.	15087-01-1
Molecular Formula	C24H31NaO8
Molecular Weight	470.49 g/mol
Synonyms	Estrone 3-Glucuronide Sodium Salt; E1-3G Sodium Salt; Sodium Estrone-3-Glucuronide; 3-Hydroxyestra-1,3,5(10)-trien-17-one 3-β-D-glucopyranosiduronic acid sodium salt; Estrone 3-β-D-Glucuronide Sodium Salt; NSC 113233; Estra-1,3,5(10)-trien-17-one, 3-(β-D-glucopyranosiduronic acid), sodium salt
EINECS	Contact for details

Quality Control

Our 1,3,5[10]-Estratrien-3-Ol-17-One 3-Glucuronide Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.