Description

4-tert-Butylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, introducing the bulky and lipophilic 4-tert-butylbenzenesulfonyl group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create sulfonamides, sulfonate esters, and other functionalized intermediates with tailored properties.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs with potential biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the tert-butyl group can influence compound lipophilicity and stability.
• Polymer Chemistry: Acts as a functional monomer or chain-transfer agent in the production of specialty polymers and resins with specific surface or solubility characteristics.
• Dye and Pigment Manufacturing: Employed in the synthesis of sulfonated dyes and colorants to enhance water solubility and fiber affinity.
• Chemical Research & Development: A valuable tool in medicinal chemistry and material science for structure-activity relationship (SAR) studies and molecular design.
• Ligand and Catalyst Preparation: Used to synthesize specialized ligands for metal complexes and catalysts used in asymmetric synthesis.

Basic Information

Item	Detail
Product Name	4-tert-Butylbenzenesulfonyl Chloride
CAS No.	15084-51-2
Molecular Formula	C10H13ClO2S
Molecular Weight	232.72 g/mol
Synonyms	p-tert-Butylbenzenesulfonyl Chloride; 4-(1,1-Dimethylethyl)benzenesulfonyl Chloride; 4-tert-Butylphenylsulfonyl Chloride; PTBS-Cl; TBSC; Benzenesulfonyl chloride, 4-(1,1-dimethylethyl)-; 1-(tert-Butyl)-4-(chlorosulfonyl)benzene
EINECS	239-142-0

Quality Control

Our 4-tert-Butylbenzenesulfonyl Chloride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with water and strong bases; ensure containers are sealed under an inert atmosphere if necessary and kept away from moisture and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.