Description

(R)-(-)-2-Amino-2-Methylbutanedioic Acid is a high-purity, single-enantiomer chiral building block and intermediate of significant importance in asymmetric synthesis. Its value lies in its unique stereochemistry, which is critical for imparting specific biological activity and optical purity in final compounds. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Asymmetric Synthesis: Used as a starting material or resolving agent in stereoselective chemical reactions to construct complex molecules with high enantiomeric excess.
• Agrochemical Research: Serves as a precursor in the synthesis of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry affects efficacy and environmental profile.
• Peptide Mimetics & Conformationally Restricted Analogs: Incorporated into peptide backbones to create analogs with enhanced metabolic stability and receptor selectivity.
• Ligand Synthesis for Catalysis: Used to prepare chiral ligands for metal-catalyzed reactions, such as asymmetric hydrogenations.
• Biochemical Research: Employed in studies of enzyme mechanisms and as a substrate or inhibitor for glutamate-related enzymes and receptors.

Basic Information

Product Name	(R)-(-)-2-Amino-2-Methylbutanedioic Acid
CAS No.	14603-76-0
Molecular Formula	C5H9NO4
Molecular Weight	147.13 g/mol
Synonyms	(R)-2-Amino-2-methylsuccinic Acid; (R)-2-Methylaspartic Acid; D-2-Methylaspartic Acid; (2R)-2-Amino-2-methylbutanedioic Acid; (R)-(-)-2-Methylaspartate; (R)-α-Methylaspartic Acid
EINECS	Contact for details

Quality Control

Our (R)-(-)-2-Amino-2-Methylbutanedioic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.