Description

L-Tyrosine, [1-14C]- is a carbon-14 labeled isotopologue of the essential amino acid L-Tyrosine, specifically radiolabeled at the 1-position of the aromatic ring. This compound is a critical tool for tracing metabolic pathways and studying protein synthesis, amino acid transport, and neurotransmitter biosynthesis in biochemical and pharmacological research. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical industries for advanced tracer studies and analytical method development.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis and catabolism of catecholamines (dopamine, norepinephrine, epinephrine) and thyroid hormones.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-derived pharmaceuticals.
• Protein and Peptide Research: Incorporated into proteins to study protein turnover, folding, and localization in cell culture and in vivo models.
• Enzyme Activity Assays: Serves as a substrate for enzymes such as tyrosine hydroxylase, tyrosine aminotransferase, and tyrosine kinases in kinetic studies.
• Agricultural Biochemistry: Applied in research on plant amino acid metabolism and the development of herbicides or plant growth regulators.
• Diagnostic Agent Development: A potential precursor in the research and development of radiolabeled diagnostic imaging agents for PET or SPECT.

Basic Information

Product Name	L-Tyrosine, [1-14C]-
CAS No.	14330-68-8
Molecular Formula	C9H1114CNO3
Molecular Weight	Contact for details
Synonyms	(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic-1-14C acid; L-Tyrosine-1-14C; L-4-Hydroxyphenylalanine-1-14C; Tyrosine-1-14C; [1-14C]-L-Tyrosine; (S)-Tyrosine-1-14C; 3-(4-Hydroxyphenyl)-L-alanine-1-14C
EINECS	Contact for details

Quality Control

Every batch of L-Tyrosine, [1-14C]- is produced and analyzed under strict quality systems to ensure high radiochemical purity, specific activity, and chemical identity. Our quality control protocols are designed to meet the stringent requirements of research and regulatory applications. A comprehensive Certificate of Analysis (COA) detailing radiochemical purity (by HPLC), specific activity, chemical purity, and solvent content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 98%
Solvent (by 1H NMR)	Meets release criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.