Description

5-Bromo-3-Methyl-3H-Pyrimidin-4-One is a versatile halogenated pyrimidinone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique bromine substitution pattern makes it a valuable building block for constructing complex heterocyclic systems with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other biologically active molecules targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution, enabling structural diversification.
• Academic & Contract Research: Essential for methodological studies and library synthesis in medicinal and synthetic chemistry laboratories worldwide.

Basic Information

Product Name	5-Bromo-3-Methyl-3H-Pyrimidin-4-One
CAS No.	14248-02-3
Molecular Formula	C5H5BrN2O
Molecular Weight	189.01 g/mol
Synonyms	5-Bromo-3-methylpyrimidin-4(3H)-one; 5-Bromo-3-methyl-4(3H)-pyrimidinone; 3-Methyl-5-bromo-4-pyrimidinol; 4(3H)-Pyrimidinone, 5-bromo-3-methyl-; 5-Bromo-3-methyl-4-hydroxypyrimidine; 5-Bromo-3-methyluracil (common misnomer, related structure)
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-3-Methyl-3H-Pyrimidin-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.