Description

(R)-3-Carboxy-4-Hydroxyphenylglycine is a high-purity, chiral phenylglycine derivative of significant importance in advanced pharmaceutical and biochemical research. This compound serves as a critical chiral building block and a potent, selective antagonist for group II metabotropic glutamate receptors (mGluRs). It is primarily sought after by research institutions and pharmaceutical developers engaged in neuroscience, medicinal chemistry, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Neuroscience Research: As a selective antagonist for group II metabotropic glutamate receptors (mGluR2/3), it is a vital pharmacological tool for studying neurological pathways, synaptic plasticity, and potential therapeutic targets for disorders like anxiety, depression, and schizophrenia.
• Medicinal Chemistry & Drug Discovery: Used as a sophisticated chiral intermediate or a lead compound scaffold in the design and synthesis of novel central nervous system (CNS) active drugs.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays and receptor binding studies to identify new modulators of glutamate receptors.
• Pharmaceutical Intermediate: Functions as a key chiral building block in the multi-step synthesis of complex, optically active pharmaceutical compounds, ensuring the desired stereochemical outcome.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	(R)-3-Carboxy-4-Hydroxyphenylglycine
CAS No.	13861-03-5
Molecular Formula	C9H9NO6
Molecular Weight	227.17 g/mol
Synonyms	(R)-3-Carboxy-4-hydroxyphenylglycine; (R)-4-Carboxy-3-hydroxyphenylglycine; (R)-CHPG; (R)-3-Carboxy-4-hydroxy-DL-phenylglycine; (2R)-2-Amino-2-(3-carboxy-4-hydroxyphenyl)acetic acid; mGluR2/3 Antagonist (R)-CHPG; L-CCG-I isomer antagonist
EINECS	Contact for details

Quality Control

Every batch of (R)-3-Carboxy-4-Hydroxyphenylglycine is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support research and development requirements, including chiral purity verification. A detailed Certificate of Analysis (COA) specifying identity, purity (by HPLC), chiral excess, and impurity profile is supplied with each shipment to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.