Description

Boc-Arg(Tos)-Oh is a protected derivative of the amino acid L-arginine, featuring tert-butoxycarbonyl (Boc) and tosyl (Tos) protecting groups on its side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of arginine residues into peptide chains.
• Pharmaceutical Research: Used in the development and production of peptide-based drugs targeting cardiovascular diseases, cancer, and metabolic disorders.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and research applications.
• Enzyme Substrate Synthesis: Employed to prepare specific peptide substrates for studying protease and kinase activity.
• Antibiotic Peptide Production: A crucial component in synthesizing antimicrobial peptides (AMPs) with arginine-rich sequences.
• Biochemical Reagent Manufacturing: Used to produce high-purity reagents for cell signaling studies and protein interaction assays.

Basic Information

Product Name	Boc-Arg(Tos)-Oh
CAS No.	13836-37-8
Molecular Formula	C19H30N4O6S
Molecular Weight	442.53 g/mol
Synonyms	Nα-Boc-Nω-tosyl-L-arginine; Boc-L-arginine(Tos)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-5-(3-methyl-4-(tosyl)guanidino)pentanoic acid; tert-Butyloxycarbonyl-arginine(tosyl)-OH; Boc-Arg(Tos)-OH; BOC-ARG(TOS); Boc-NG-Tosyl-L-arginine; Nα-Boc-Nω-nitro-L-arginine (common related compound)
EINECS	Contact for details

Quality Control

Our Boc-Arg(Tos)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -12.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.