Description

4-(Trifluoromethyl)Pyrimidine-2-Thiol is a high-value heterocyclic building block characterized by its pyrimidine core functionalized with a thiol group and a trifluoromethyl substituent. This compound is essential for its role in facilitating the synthesis of complex molecules, where the trifluoromethyl group enhances lipophilicity and metabolic stability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis or for creating novel organic frameworks with specific electronic properties.
• Chemical Biology Probe Development: Utilized in designing molecular probes and inhibitors to study enzyme function and biological pathways, leveraging the reactive thiol group for conjugation.

Basic Information

Product Name	4-(Trifluoromethyl)Pyrimidine-2-Thiol
CAS No.	13654-17-6
Molecular Formula	C5H3F3N2S
Molecular Weight	180.15 g/mol
Synonyms	2-Mercapto-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-pyrimidinethiol; 2-Pyrimidinethiol, 4-(trifluoromethyl)-; 4-Trifluoromethyl-2-mercaptopyrimidine; 2-Thiol-4-trifluoromethylpyrimidine; 4-(Trifluoromethyl)pyrimidine-2-thione (tautomer); 13654-17-6; 4-CF3-Pyrimidine-2-thiol
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyrimidine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.