Description

2-Thiolhistidine is a sulfur-containing derivative of the amino acid histidine, characterized by the presence of a thiol (-SH) group. This unique structure makes it a valuable biochemical building block and research compound for studying redox biology and enzyme mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in peptide synthesis, biochemical research, and as a potential precursor for specialized active pharmaceutical ingredients (APIs).

Application

• Biochemical Research & Development: Used as a specialized amino acid analog to study enzyme active sites, metal-binding properties, and redox processes in biological systems.
• Peptide Synthesis: Serves as a building block for the solid-phase or solution-phase synthesis of novel peptides and peptidomimetics with modified properties.
• Pharmaceutical Intermediates: Acts as a key precursor or intermediate in the synthesis of more complex molecules with potential therapeutic applications.
• Nutritional Science Studies: Employed in metabolic pathway research and studies related to sulfur amino acid metabolism.
• Antioxidant Research: Investigated for its potential role in modulating oxidative stress due to its thiol functionality.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Thiolhistidine
CAS No.	13552-61-9
Molecular Formula	C6H9N3O2S
Molecular Weight	187.22 g/mol
Synonyms	2-Mercaptohistidine; L-2-Thiolhistidine; (2S)-2-Amino-3-(1H-imidazol-4-yl)-2-sulfanylpropanoic acid; 2-Sulfanyl-L-histidine; Histidine, 2-mercapto-; 2-Thiohistidine; 2-SH-His
EINECS	Contact for details

Quality Control

Our 2-Thiolhistidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assay by HPLC, and control of related substances and residual solvents. We provide full traceability and support our customers with detailed Certificates of Analysis (COA) upon request, ensuring compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.