Description

D-Kynurenine is a specific enantiomer of the endogenous tryptophan metabolite kynurenine, distinguished by its D-configuration. This compound is a critical chiral building block and reference standard in biochemical research, particularly for studying the kynurenine pathway's role in neurological and immunological processes. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors who require high-purity, enantiomerically pure compounds for assay development, metabolic studies, and drug discovery.

Application

• Biochemical Research: Used as a chiral reference standard and substrate in enzymatic studies of the kynurenine pathway, which is implicated in neuroinflammation, neurodegeneration, and immune regulation.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and development of novel therapeutics targeting neurological disorders (e.g., Alzheimer's, Parkinson's, depression) and cancer immunotherapy.
• Metabolomics & Diagnostics: Employed in the calibration and validation of analytical methods (HPLC, LC-MS) for the precise quantification of kynurenine pathway metabolites in biological samples.
• Enzyme Inhibition Studies: Acts as a specific substrate for enzymes like kynureninase and kynurenine aminotransferase, facilitating the screening and characterization of potential enzyme inhibitors.
• Nutritional Science Research: Utilized in studies investigating the impact of diet and gut microbiota on tryptophan metabolism and systemic health outcomes.

Basic Information

Product Name	D-Kynurenine
CAS No.	13441-51-5
Molecular Formula	C10H12N2O3
Molecular Weight	208.21 g/mol
Synonyms	D-(-)-Kynurenine; (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic Acid; (R)-Kynurenine; D-α-Amino-β-(o-aminobenzoyl)propionic Acid; (R)-2-Amino-4-(2-aminobenzoyl)butanoic Acid; D-KYN; D-Kyn
EINECS	Contact for details

Quality Control

Our D-Kynurenine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and enantiomeric excess meet exacting standards. A detailed Certificate of Analysis (COA) providing batch-specific results for assay, chiral purity, and related substances is supplied with every shipment to guarantee traceability and consistency for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.