Description

n-Formyl-L-Tyrosine is a chemically modified derivative of the essential amino acid L-Tyrosine, where a formyl group protects the amine functionality. This modification is crucial in peptide synthesis, particularly in solid-phase methodologies, as it prevents unwanted side reactions and allows for selective deprotection. It serves as a key protected intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require high-purity building blocks for peptide-based drug discovery and development.

Application

• Peptide Synthesis Intermediate: A fundamental building block (Fmoc or Boc strategy) for the controlled assembly of complex peptides and proteins in both research and GMP manufacturing.
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic peptides, including hormone analogs, enzyme inhibitors, and targeted drug conjugates.
• Bioconjugation & Probe Development: The protected amine allows for the site-specific introduction of labels, tags, or linkers to create biochemical probes and antibody-drug conjugates (ADCs).
• Biocatalyst & Enzyme Studies: Serves as a substrate or inhibitor analog in enzymatic studies to understand tyrosine kinase and phosphatase mechanisms.
• Chemical Biology Tool: Employed to incorporate tyrosine analogs into proteins to study post-translational modifications like phosphorylation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.

Basic Information

Product Name	n-Formyl-L-Tyrosine
CAS No.	13200-86-7
Molecular Formula	C10H11NO4
Molecular Weight	209.20 g/mol
Synonyms	N-Formyl-L-tyrosine; (2S)-2-Formamido-3-(4-hydroxyphenyl)propanoic Acid; L-Tyrosine, N-formyl-; F-Tyr-OH; N-For-Tyr-OH; Formyltyrosine; NSC 3344; Tyrosine, N-formyl-
EINECS	Contact for details

Quality Control

Our n-Formyl-L-Tyrosine is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity ([α]D)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.