Description

Z-His-Ala-Oh is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z)-protected form of histidyl-alanine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), offering controlled reactivity for the sequential assembly of complex peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected intermediate for the controlled elongation of peptide chains.
• Pharmaceutical Research: Used in the R&D of peptide hormones, enzyme inhibitors, and other bioactive peptide sequences containing the His-Ala motif.
• Bioconjugation: Acts as a spacer or functional component in the synthesis of peptide-protein conjugates.
• Biochemical Reagent: Employed as a standard or substrate in enzymatic studies and proteomics research.
• Custom Peptide Manufacturing: A fundamental raw material for CROs and CDMOs producing bespoke peptides for clients.

Basic Information

Product Name	Z-His-Ala-Oh
CAS No.	13056-38-7
Molecular Formula	C16H20N4O5
Molecular Weight	348.35 g/mol
Synonyms	Nα-Cbz-L-histidyl-L-alanine; N-Carbobenzoxy-L-histidyl-L-alanine; Cbz-His-Ala-OH; Z-L-His-L-Ala-OH; Benzyloxycarbonyl-L-histidyl-L-alanine; Nα-Z-L-histidyl-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid (common mis-assignment check); CBZ-HISTIDYL-ALANINE
EINECS	Contact for details

Quality Control

Our Z-His-Ala-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.