Description

Z-His-Gly-Oh is a protected dipeptide derivative featuring a benzyloxycarbonyl (Z) group on the histidine residue. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), where it is used to introduce the His-Gly sequence while preventing unwanted side reactions. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a protected fragment in academic and industrial research for studying protein-protein interactions and enzyme substrates.
• Peptide Library Construction: Essential building block in combinatorial chemistry for generating diverse peptide libraries for drug discovery screening.
• Diagnostic Reagent Synthesis: Intermediate in the production of labeled peptides for immunoassays and other diagnostic applications.
• Cosmeceutical Peptides: Potential precursor for bioactive peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	Z-His-Gly-Oh
CAS No.	13056-37-6
Molecular Formula	C16H20N4O5
Molecular Weight	348.36 g/mol
Synonyms	Nα-Cbz-L-Histidyl-Glycine; N-Carbobenzoxy-L-histidylglycine; Z-L-Histidyl-Glycine; Cbz-His-Gly-OH; Nα-Benzyloxycarbonyl-L-histidylglycine; Benzyl N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamate; Z-His-Gly; CBZ-HIS-GLY-OH
EINECS	Contact for details

Quality Control

Our Z-His-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.