Description

Z-His-Phe-Oh CAS NO 13053-69-5 is a high-purity, protected dipeptide derivative, specifically the benzyloxycarbonyl (Z)-protected form of histidyl-phenylalanine. This compound serves as a critical building block (amino acid derivative) in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly in developing novel therapeutic peptides and biochemical tools.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of longer, biologically active peptide chains for drug discovery and development.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, receptor-ligand interaction assays, and metabolic pathway research.
• Peptide Library Synthesis: A fundamental component in combinatorial chemistry for creating diverse peptide libraries for screening.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) that contain the His-Phe sequence.
• Neuroscience Research: Potential use in synthesizing peptide analogs for studying neurological functions and disorders.

Basic Information

Product Name	Z-His-Phe-Oh
CAS No.	13053-69-5
Molecular Formula	C₂₂H₂₄N₄O₅
Molecular Weight	424.45 g/mol
Synonyms	Z-His-Phe-OH; Z-Histidyl-Phenylalanine; Nα-CBZ-L-Histidyl-L-Phenylalanine; CBZ-L-His-L-Phe-OH; N-Carbobenzoxy-L-histidyl-L-phenylalanine; Benzyloxycarbonyl-L-histidyl-L-phenylalanine; Z-L-His-L-Phe-OH; L-Phenylalanine, N-[N-[(benzyloxy)carbonyl]-L-histidyl]-
EINECS	Contact for details

Quality Control

Our Z-His-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.