Description

Z-His-Tyr-Tyr-Oet is a synthetic tripeptide derivative, specifically an ethyl ester, featuring a unique sequence of histidine and tyrosine residues. This compound is a crucial building block and research intermediate in advanced pharmaceutical and biochemical development. It is primarily utilized by researchers and manufacturers in the fields of peptide synthesis, medicinal chemistry, and proteomics for investigating enzyme-substrate interactions and developing novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of more complex peptide-based drug candidates and bioactive molecules.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving proteases or kinases that recognize histidine and tyrosine motifs.
• Medicinal Chemistry: Acts as a scaffold for structure-activity relationship (SAR) studies to optimize peptide stability, bioavailability, and target affinity.
• Proteomics & Signal Transduction: Employed in research focused on phosphorylation events and tyrosine-based signaling pathways.
• Academic & Institutional Laboratories: Utilized in fundamental research exploring peptide conformation, folding, and molecular recognition.
• Custom Peptide Synthesis: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides for clients.

Basic Information

Product Name	Z-His-Tyr-Tyr-Oet
CAS No.	13053-63-9
Molecular Formula	C33H38N6O8
Molecular Weight	646.69 g/mol
Synonyms	Z-His-Tyr-Tyr-OEt; Nα-Carbobenzoxy-L-histidyl-L-tyrosyl-L-tyrosine ethyl ester; CBZ-His-Tyr-Tyr-OEt; Benzyloxycarbonyl-L-histidyl-L-tyrosyl-L-tyrosine ethyl ester; Z-H-Y-Y-OEt; N-CBZ-L-Histidyl-L-Tyrosyl-L-Tyrosine Ethyl Ester; (S)-Ethyl 2-(2-(2-((((benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoate
EINECS	Contact for details

Quality Control

Our Z-His-Tyr-Tyr-Oet is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.