Description

Dl-Normetanephrine Hydrochloride CAS NO 13015-71-9 is a hydrochloride salt of a key catecholamine metabolite, serving as a critical reference standard and intermediate in biochemical research and pharmaceutical development. Its primary value lies in enabling precise analytical quantification and metabolic pathway studies related to neurotransmitters like norepinephrine and epinephrine. This compound is essential for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and life science sectors, where accurate biomarker measurement is paramount.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (e.g., HPLC, LC-MS) in drug metabolism and pharmacokinetics (DMPK) studies.
• Clinical Diagnostics: Serves as a critical calibrator and control in assays for quantifying normetanephrine levels in plasma or urine, aiding in the diagnosis of pheochromocytoma and paraganglioma.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate catechol-O-methyltransferase (COMT) activity and catecholamine metabolic pathways.
• Neuropharmacology: Utilized in research exploring sympathetic nervous system function, stress response, and the mechanisms of adrenergic agents.
• Impurity Standard: Acts as a known impurity standard in the quality control of pharmaceutical formulations containing related adrenergic compounds.

Basic Information

Product Name	Dl-Normetanephrine Hydrochloride
CAS No.	13015-71-9
Molecular Formula	C9H14ClNO3
Molecular Weight	219.66 g/mol
Synonyms	DL-Normetanephrine HCl; (±)-Normetanephrine Hydrochloride; 3-Methoxy-4-hydroxyphenylethanolamine Hydrochloride; 4-Hydroxy-3-methoxyphenylethanolamine Hydrochloride; DL-3-O-Methylepinephrine Hydrochloride; Nor-Metanephrine Hydrochloride (racemic); 1-(3-Methoxy-4-hydroxyphenyl)-2-aminoethanol Hydrochloride
EINECS	Contact for details

Quality Control

Our Dl-Normetanephrine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-purity standards suitable for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.