Description

Fmoc-D-Asp(Otbu)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled incorporation of D-aspartic acid into complex peptide chains, enabling the research and development of novel therapeutic peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in peptide-based drug discovery and process development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of peptides using Fmoc-chemistry protocols.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic Development: Incorporation of non-natural amino acid structures to enhance metabolic stability and bioavailability of peptide leads.
• Bioconjugation: Used in the preparation of peptide-protein or peptide-small molecule conjugates for diagnostic and therapeutic applications.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify bioactive peptide sequences.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Fmoc-D-Asp(Otbu)-Oh
CAS No.	12883-39-3
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-D-aspartic acid 4-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic acid 4-tert-butyl ester; Fmoc-D-Asp(OtBu)-OH; Fmoc-D-Asp(OtBu); N-Fmoc-D-aspartic acid β-tert-butyl ester; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)succinic acid 4-tert-butyl ester; Fmoc-D-Asp(OBut)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asp(Otbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.