Description

5,5'-Dihydroxylysylnorleucine is a specialized biochemical compound, a cross-linked amino acid derivative that serves as a key biomarker for connective tissue metabolism. Its primary commercial value lies in its role as a specific indicator for collagen degradation and turnover, making it critical for research and diagnostic applications. This product is essential for biochemical researchers, clinical diagnostic developers, and pharmaceutical companies focused on metabolic bone diseases, arthritis, and tissue repair studies.

Application

• Biochemical Research: Used as a reference standard and reagent in studies of collagen catabolism, lysyl oxidase activity, and advanced glycation end-products (AGEs).
• Clinical Diagnostics: Serves as a critical calibrator and control in the development of immunoassays (ELISA) for quantifying pyridinoline cross-links in biological fluids like urine and serum.
• Pharmaceutical Development: Employed in drug discovery programs targeting conditions like osteoporosis, osteoarthritis, and fibrosis, where collagen turnover is a key pathological marker.
• Nutritional Science: Used in research investigating the impact of diet and supplements on bone health and connective tissue integrity.
• Toxicology Studies: Applied in assessing the effects of various compounds on collagen stability and connective tissue health.

Basic Information

Product Name	5,5'-Dihydroxylysylnorleucine
CAS No.	12764-49-7
Molecular Formula	C14H28N4O6
Molecular Weight	348.40 g/mol
Synonyms	DHLNL; 5,5'-Dihydroxylysinonorleucine; Bis(5-hydroxy-5-carboxypentyl)amine; Hydroxylysylnorleucine; Lysyl oxidase crosslink; Collagen cross-link; Pyridinoline precursor; (2S)-2-Amino-6-{[(2S)-2-amino-6-hydroxyhexyl]amino}hexanoic acid
EINECS	Contact for details

Quality Control

Our 5,5'-Dihydroxylysylnorleucine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality system supports compliance with relevant standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under desiccant when not in use. For long-term storage, consider keeping the product at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.