Description

α-Cobratoxin From Naja Atra CAS NO 12584-83-7 is a highly purified, long-chain postsynaptic neurotoxin isolated from the venom of the Chinese cobra (Naja atra). This specific polypeptide toxin is a critical research tool for studying nicotinic acetylcholine receptors (nAChRs) due to its potent and selective antagonistic activity. It is essential for neuroscience and pharmacology research, particularly in receptor characterization, neurological disorder modeling, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective antagonist for muscle-type and neuronal α7 nAChRs, it is used to block receptor activity in electrophysiology, calcium imaging, and behavioral studies.
• Pharmacological Studies: Employed in the screening and characterization of new drugs targeting the cholinergic system, including potential analgesics and neuroprotective agents.
• Biochemical Assay Development: Used as a standard or reference compound in developing high-throughput screening (HTS) assays and binding studies (e.g., radio-ligand binding assays).
• Toxicology & Venom Research: Serves as a key component in comparative venom studies, antivenom efficacy testing, and understanding snakebite pathophysiology.
• Diagnostic Tool Development: Potential use in creating biosensors or diagnostic kits for detecting specific nAChR subtypes or related autoimmune conditions.
• Cell Signaling Pathway Analysis: Applied to investigate the role of nAChRs in cell proliferation, apoptosis, and inflammatory responses in various cell lines.

Basic Information

Product Name	α-Cobratoxin From Naja Atra
CAS No.	12584-83-7
Molecular Formula	C264H402N74O75S7
Molecular Weight	~7823.0 g/mol
Synonyms	α-Cobratoxin; Naja atra Neurotoxin; Cobra Neurotoxin α; Long Neurotoxin; α-Neurotoxin; CTX; α-Cobrotoxin; Postsynaptic Neurotoxin
EINECS	Contact for details

Quality Control

Our α-Cobratoxin is produced and purified under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to a comprehensive suite of analytical tests, including reversed-phase HPLC for purity, mass spectrometry for identity confirmation, and biological activity assays. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, potency, and endotoxin levels to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (LD50 assay)	Contact for details
Protein Content (UV)	≥ 90%
Endotoxin Level (LAL)	< 10 EU/mg
Solubility	Soluble in water or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.