Description

α-Bungarotoxin is a potent, long-chain neurotoxin peptide isolated from the venom of the many-banded krait (*Bungarus multicinctus*). This compound is a highly selective and irreversible antagonist of nicotinic acetylcholine receptors (nAChRs), specifically targeting the α-7 and muscle-type subtypes. It is an indispensable research tool for neuroscientists, pharmacologists, and toxicologists studying cholinergic signaling, receptor structure and function, and neuromuscular junction biology. α-Bungarotoxin CAS NO 11032-79-4 is critical for applications in receptor mapping, electrophysiology, and the development of therapeutic agents for neurological disorders.

Application

• Neuroscience Research: Irreversible blockade of neuronal and muscle-type nicotinic acetylcholine receptors (nAChRs) for functional studies.
• Receptor Mapping & Labeling: Used conjugated with fluorescent or biotin tags to visualize and localize nAChR distribution in tissues and cells.
• Electrophysiology: A standard pharmacological tool to characterize synaptic transmission and receptor kinetics at the neuromuscular junction and in neuronal circuits.
• Drug Discovery & Screening: Employed in assays to identify and evaluate novel compounds that modulate nAChR activity for treating conditions like myasthenia gravis, Alzheimer's disease, and nicotine addiction.
• Toxicology Studies: Serves as a reference toxin for understanding snake venom mechanisms and developing antivenoms.
• Biochemical Assays: Used in affinity purification and isolation of nAChR proteins from complex biological samples.

Basic Information

Product Name	α-Bungarotoxin
CAS No.	11032-79-4
Molecular Formula	C264H420N84O79S7 (Approx., for main isoform)
Molecular Weight	~7983 g/mol (Monoisotopic)
Synonyms	α-Bungarotoxin; α-BGT; Bungarotoxin, α-; Bungarus multicinctus venom toxin alpha; Nicotinic acetylcholine receptor antagonist α-Bgt; Long-chain neurotoxin α; Acetylcholine receptor protein α-bungarotoxin; α-Neurotoxin
EINECS	Contact for details

Quality Control

Our α-Bungarotoxin is produced and tested to meet the exacting standards required for life science research. Each batch undergoes rigorous analytical characterization to ensure high purity, biological activity, and consistency. Quality assurance includes testing for potency via receptor binding assays and purity assessment via HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, biological activity (IC50), endotoxin levels, and analytical profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C, avoiding repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (nAChR binding)	≥ 95% of reference standard
Protein Content (UV)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.