Description

H-D-Ala-D-Ala-D-Ala-D-Ala-D-Ala-Oh is a synthetic, homochiral pentapeptide composed entirely of D-alanine residues, a structural motif of significant interest in biochemical research. This compound matters as a specialized building block and model substrate for studying peptide conformation, enzyme specificity, and bacterial cell wall biosynthesis, particularly related to vancomycin resistance. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, antibiotic mechanism studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a model peptide substrate for studying the binding mechanisms of glycopeptide antibiotics like vancomycin.
• Enzymology Studies: Serves as a specific substrate or inhibitor for enzymes involved in bacterial cell wall synthesis, such as D,D-peptidases and D,D-transpeptidases.
• Pharmaceutical Development: Acts as a key intermediate or reference standard in the research and development of new antimicrobial agents targeting resistant bacteria.
• Peptide Conformation Analysis: Utilized in spectroscopic studies (NMR, CD) to investigate the structural properties and stability of poly-D-alanine sequences.
• Synthetic Chemistry: Employed as a chiral building block for the solid-phase or solution-phase synthesis of more complex, custom-designed peptides.

Basic Information

Item	Details
Product Name	H-D-Ala-D-Ala-D-Ala-D-Ala-D-Ala-Oh
CAS No.	10491-09-5
Molecular Formula	C15H27N5O6
Molecular Weight	373.41 g/mol
Synonyms	Pentakis(D-alanine); D-Alanine pentamer; H-D-Ala-D-Ala-D-Ala-D-Ala-D-Ala-OH; Penta-D-alanine; (D-Ala)5; D-Ala-D-Ala-D-Ala-D-Ala-D-Ala; N-(D-Alanyl)-D-alanyl-D-alanyl-D-alanyl-D-alanine; Poly-D-alanine (n=5)
EINECS	Contact for details

Quality Control

Our H-D-Ala-D-Ala-D-Ala-D-Ala-D-Ala-Oh is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.