Description

3-Iodo-L-Thyronine is a halogenated derivative of the thyroid hormone thyronine, serving as a key intermediate and reference standard in biochemical research. This compound is critical for studying thyroid hormone metabolism, receptor binding, and the development of novel diagnostic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for life science applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel thyroid hormone analogs and potential therapeutic agents.
• Biochemical Research: Used as a reference standard and tracer in studies of thyroid hormone action, metabolism, and transport mechanisms.
• Diagnostic Development: Serves as a precursor or standard in the development of immunoassays and other diagnostic tests for thyroid function.
• Metabolite Studies: Employed in metabolic pathway analysis to understand the biotransformation of thyroid hormones.
• Endocrinology Research: A vital tool for investigating hormone-receptor interactions and signal transduction pathways related to thyroid function.
• Fine Chemical Synthesis: Used in the preparation of specialized, high-value compounds for research and development purposes.

Basic Information

Item	Details
Product Name	3-Iodo-L-Thyronine
CAS No.	10468-90-3
Molecular Formula	C15H14INO4
Molecular Weight	423.18 g/mol
Synonyms	3-Iodo-L-thyronine; 3-Iodothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; 3'-Monoiodothyronine; 3'-T1; 3'-Triiodothyronine impurity; L-3'-Iodothyronine; 3-Iodo-3'-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine
EINECS	Contact for details

Quality Control

Our 3-Iodo-L-Thyronine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. While not a USP/NF monograph item, production can adhere to cGMP principles for research-grade materials upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.