Description

2-Chloro-5-Nitropyrimidine is a versatile and high-value halogenated nitropyrimidine building block essential for advanced organic synthesis. Its core value lies in its dual reactive sites—the chloro and nitro groups—which enable precise, sequential functionalization to construct complex heterocyclic systems. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides with specific modes of action.
• Chemical Research & Development: Serves as a fundamental scaffold for exploring new chemical entities and reaction pathways in medicinal chemistry.
• Material Science: Potential building block for creating specialty polymers and functional materials with unique electronic properties.
• Custom Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	2-Chloro-5-Nitropyrimidine
CAS No.	10320-42-0
Molecular Formula	C4H2ClN3O2
Molecular Weight	159.53 g/mol
Synonyms	5-Nitro-2-chloropyrimidine; 2-Chloro-5-nitropyrimidine; 2-Chloro-5-nitro-1,3-diazine; Pyrimidine, 2-chloro-5-nitro-; 2-Chlor-5-nitropyrimidin (German); 2-クロロ-5-ニトロピリミジン (Japanese); 2-氯-5-硝基嘧啶 (Chinese)
EINECS	233-707-7

Quality Control

Our 2-Chloro-5-Nitropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring reliable and reproducible performance in critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed and stored in a dry environment.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.