Description

(2S,3S)-2-Amino-3-Hydroxy-4-Methyl-Pentanoic Acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical chiral building block and intermediate for the synthesis of complex molecules, including peptide-based therapeutics and enzyme inhibitors. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other bioactive peptides.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway analysis.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) and develop novel therapeutic candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in the preparation of enantiomerically pure compounds.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S,3S)-2-Amino-3-Hydroxy-4-Methyl-Pentanoic Acid
CAS No.	10148-70-6
Molecular Formula	C6H13NO3
Molecular Weight	147.17 g/mol
Synonyms	(2S,3S)-2-Amino-3-hydroxy-4-methylpentanoic acid; L-threo-3-Hydroxy-L-isoleucine; (2S,3S)-3-Hydroxyisoleucine; allo-3-Hydroxy-L-isoleucine; (2S,3S)-3-Hydroxy-L-isoleucine; 3-Hydroxy-L-isoleucine (threo); 2-Amino-3-hydroxy-4-methylpentanoic acid (2S,3S)-; H-Ile(3-OH)-OH
EINECS	Contact for details

Quality Control

Our (2S,3S)-2-Amino-3-Hydroxy-4-Methyl-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.