Description

Z-His-Phe-Trp-Oet is a synthetic tripeptide derivative, specifically the ethyl ester of the Z-protected sequence Histidine-Phenylalanine-Tryptophan. This compound is a crucial building block in peptide synthesis and pharmaceutical research, offering a protected intermediate for constructing more complex bioactive peptides. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the development of novel peptide-based therapeutics and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a key protected fragment in the solid-phase or solution-phase synthesis of complex peptide drugs and candidates.
• Biochemical Research: Used as a standard or substrate in enzymatic studies, receptor-ligand interaction assays, and metabolic pathway investigations.
• Peptide Library Construction: An essential component for generating combinatorial peptide libraries for high-throughput screening in drug discovery.
• Academic & R&D: Employed in university and institutional laboratories for studying peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis services catering to the biotech and pharmaceutical industries.

Basic Information

Item	Details
Product Name	Z-His-Phe-Trp-Oet
CAS No.	10119-01-4
Molecular Formula	C₃₇H₄₁N₇O₆
Molecular Weight	679.77 g/mol
Synonyms	Z-His-Phe-Trp-OEt; N-Benzyloxycarbonyl-L-histidyl-L-phenylalanyl-L-tryptophan ethyl ester; CBZ-His-Phe-Trp-OEt; Benzyloxycarbonyl-L-histidyl-L-phenylalanyl-L-tryptophan ethyl ester; Z-HFW-OEt; Z-Histidine-Phenylalanine-Tryptophan ethyl ester; Nα-CBZ-L-Histidyl-L-Phenylalanyl-L-Tryptophan Ethyl Ester; L-Histidine, N2-[(phenylmethoxy)carbonyl]-L-phenylalanyl-L-tryptophan-, ethyl ester
EINECS	Contact for details

Quality Control

Our Z-His-Phe-Trp-Oet is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.