Description

Isodesmosine Chloride is a specialized biochemical compound of significant interest in connective tissue research and diagnostic applications. Its primary value lies in its role as a unique cross-linking amino acid derivative, specifically associated with elastin. This makes it a critical material for researchers and manufacturers in the life sciences sector, particularly those focused on developing assays for fibrosis, chronic obstructive pulmonary disease (COPD), and other conditions related to elastin degradation and turnover.

Application

• Biomarker Research & Development: Serves as a key reference standard and antigen in the development of immunoassays (ELISA) for quantifying desmosine and isodesmosine in biological fluids.
• Connective Tissue Disease Studies: Used in biochemical research to study elastin metabolism, fibrosis, pulmonary emphysema, and vascular diseases.
• Diagnostic Kit Manufacturing: An essential raw material for in-vitro diagnostic (IVD) kit producers creating tests for monitoring diseases like cystic fibrosis and COPD.
• Pharmaceutical R&D: Employed in drug discovery programs targeting elastase inhibitors and therapies aimed at modulating elastin breakdown.
• Academic & Clinical Research: Utilized as a pure standard for mass spectrometry (LC-MS/MS) and chromatographic analysis in university and hospital laboratories.
• Quality Control Reference: Acts as a certified reference material (CRM) for ensuring the accuracy and precision of analytical methods in contract research organizations (CROs).

Basic Information

Product Name	Isodesmosine Chloride
CAS No.	10059-18-4
Molecular Formula	C24H40N5O8 • HCl
Molecular Weight	556.07 g/mol
Synonyms	Isodesmosine HCl; (2S)-2-Amino-5-[(4S)-4-Amino-4-carboxybutyl]-1-(3S)-3-Amino-3-carboxypropyl]-4-(5-amino-5-carboxypentyl)imidazolium Chloride; 1,5-Dihydro-2H-imidazolium, 2-amino-5-(4-amino-4-carboxybutyl)-1-(3-amino-3-carboxypropyl)-4-(5-amino-5-carboxypentyl)-, chloride, (2S,3S,4S)-; Elastin Cross-Link Amino Acid Chloride Salt
EINECS	Contact for details

Quality Control

Our Isodesmosine Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.