Description

N-6-Trifluoroacetyl-L-Lysine is a chemically modified derivative of the essential amino acid L-Lysine, featuring a trifluoroacetyl protecting group on its ε-amino function. This modification is critical for enabling selective peptide synthesis and biochemical research where precise control over amino acid reactivity is required. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS), particularly for constructing lysine-containing sequences.
• Pharmaceutical Research: Used in the development and production of novel peptide-based therapeutics, including hormone analogs and antimicrobial peptides.
• Bioconjugation & Labeling: Facilitates the site-specific modification of proteins and peptides due to the reactivity of the protected amine group.
• Biochemical Tool Development: Employed in creating enzyme substrates, inhibitors, and probes for studying lysine-specific biological processes.
• Protecting Group Strategy: The trifluoroacetyl (Tfa) group is used in multi-step organic syntheses where orthogonal deprotection is needed.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Product Name	N-6-Trifluoroacetyl-L-Lysine
CAS No.	10009-20-8
Molecular Formula	C8H13F3N2O3
Molecular Weight	242.19 g/mol
Synonyms	Nε-Trifluoroacetyl-L-lysine; (S)-2-Amino-6-(trifluoroacetamido)hexanoic acid; L-Lysine, N6-(trifluoroacetyl)-; Tfa-L-Lys-OH; N-α-Amino-N-ε-trifluoroacetyl-L-lysine; 6-(Trifluoroacetamido)-L-norleucine; Trifluoroacetyllysine
EINECS	Contact for details

Quality Control

Our N-6-Trifluoroacetyl-L-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.