Description

Ethyl 2-Fluoro-3-Hydroxypropanoate is a valuable fluorinated building block and chiral synthon in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a hydroxyl group, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine into target molecules to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental persistence.
• Chiral Auxiliary & Ligand Precursor: Serves as a starting material for synthesizing chiral ligands, catalysts, and auxiliaries used in asymmetric synthesis.
• Fluorine Chemistry Research: A fundamental reagent in academic and industrial R&D for exploring new fluorination methodologies and creating fluorinated molecular libraries.
• Specialty Polymer Modifier: Can be incorporated into polymer backbones to impart specific characteristics like oil repellency, chemical resistance, or altered surface energy.
• Diagnostic Agent Development: Potential intermediate for radiolabeled compounds (e.g., 18F) used in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	Ethyl 2-Fluoro-3-Hydroxypropanoate
CAS No.	1993-92-6
Molecular Formula	C5H9FO3
Molecular Weight	136.12 g/mol
Synonyms	Ethyl 2-Fluoro-3-hydroxypropionate; 2-Fluoro-3-hydroxypropionic Acid Ethyl Ester; 3-Hydroxy-2-fluoropropionic Acid Ethyl Ester; Ethyl 3-Hydroxy-2-fluoropropanoate; 2-Fluoro-3-hydroxy-propanoic acid ethyl ester; Ethyl α-fluoro-β-hydroxypropionate; NSC 523777; Ethyl 2-fluoro-3-hydroxypropanoate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Fluoro-3-Hydroxypropanoate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assay, identity confirmation, and impurity profiling, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, enantiomeric excess (if applicable), and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.