Description

4-Aminomethylphenylalanine is a non-natural, chiral amino acid derivative featuring a phenylalanine backbone with an additional aminomethyl substituent on the aromatic ring. This unique structure makes it a valuable building block for the synthesis of complex peptides and peptidomimetics, offering enhanced binding affinity and metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic agents, diagnostic tools, and advanced biomaterials.

Application

• Pharmaceutical Intermediates: Critical building block for the synthesis of peptide-based drugs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetics Design: Used to create stable analogs of natural peptides with improved pharmacological properties for drug discovery.
• Bioconjugation & Linker Chemistry: The reactive amino group enables its use as a linker for attaching payloads in antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Serves as a key chiral synthon in academic and industrial research for exploring new chemical entities and biological pathways.
• Diagnostic Agent Synthesis: Employed in the production of contrast agents and molecular probes for imaging applications.

Basic Information

Product Name	4-Aminomethylphenylalanine
CAS No.	1991-96-4
Molecular Formula	C10H14N2O2
Molecular Weight	194.23 g/mol
Synonyms	4-(Aminomethyl)-L-phenylalanine; L-4-(Aminomethyl)phenylalanine; (2S)-2-Amino-3-[4-(aminomethyl)phenyl]propanoic acid; Fmoc-4-AmF-OH (when protected); 4-Aminomethyl-DL-phenylalanine (racemic mixture); Phenylalanine, 4-(aminomethyl)-; 4-Carbamidomethylphenylalanine
EINECS	Contact for details

Quality Control

Our 4-Aminomethylphenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (typically >98% by HPLC), and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.