Description

Uroporphyrinogen Iii CAS NO 1976-85-8 is a key biochemical intermediate in the heme and chlorophyll biosynthetic pathways. This compound is of critical importance for research into porphyrias and other metabolic disorders related to heme synthesis. It is primarily utilized by biochemical researchers, diagnostic kit manufacturers, and pharmaceutical R&D departments focused on metabolic pathway analysis and enzyme studies.

Application

• Biochemical Research: Essential substrate for studying the enzymatic steps in heme biosynthesis, particularly the action of uroporphyrinogen decarboxylase.
• Diagnostic Development: Used as a reference standard in the development and calibration of diagnostic assays for porphyria diseases.
• Enzyme Kinetics Studies: Employed to investigate enzyme inhibition, activity, and mechanism of action within the tetrapyrrole synthesis pathway.
• Pharmaceutical R&D: Serves as a critical intermediate in research aimed at understanding and developing treatments for metabolic disorders.
• Metabolic Pathway Analysis: Used in tracer studies and metabolic flux analysis to map and quantify heme biosynthesis in biological systems.
• Academic Teaching: A valuable compound for advanced university courses in biochemistry, enzymology, and metabolic diseases.

Basic Information

Product Name	Uroporphyrinogen Iii
CAS No.	1976-85-8
Molecular Formula	C₄₀H₄₆N₄O₁₆
Molecular Weight	838.82 g/mol
Synonyms	Uroporphyrinogen III; URO'GEN III; UPG III; 3,8,13,17-Tetrakis(2-carboxyethyl)-2,7,12,18-porphinetetracarboxylic acid (reduced form); 2,7,12,17-Tetrakis(2-carboxyethyl)-3,8,13,18-porphinetetracarboxylic acid (reduced form); Uroporphyrinogen-3; Urogen III
EINECS	217-850-7

Quality Control

Our Uroporphyrinogen III is produced and handled under strict quality protocols to ensure high purity and stability for sensitive research applications. Each batch is analyzed using advanced chromatographic techniques to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and stability data is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from all light exposure. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a dry, cool, and well-ventilated area. Allow the product to equilibrate to room temperature in the sealed, protected container before opening to minimize condensation.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in alkaline aqueous solutions
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.