Description

3-Hydroxyaspartic Acid is a non-proteinogenic amino acid derivative of aspartic acid, featuring an additional hydroxyl group on the β-carbon. This structural modification makes it a valuable chiral building block and intermediate in organic synthesis and biochemical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel compounds and studying enzymatic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of aspartate and glutamate-related enzymes.
• Peptide Synthesis: Incorporated into synthetic peptides to introduce hydroxyl functionality, altering peptide conformation, solubility, and bioactivity.
• Agrochemical Development: Acts as a precursor in the synthesis of novel herbicides or plant growth regulators that mimic natural amino acid pathways.
• Chelating Agent Research: Studied for its potential metal-chelating properties due to its multiple carboxylate and hydroxyl groups.
• Standards & Reference Material: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-Hydroxyaspartic Acid
CAS No.	1860-87-3
Molecular Formula	C4H7NO5
Molecular Weight	149.10 g/mol
Synonyms	β-Hydroxyaspartic Acid; three-3-Hydroxy-L-aspartic Acid; (2S,3S)-3-Hydroxyaspartic Acid; HOAsp; 3-Hydroxyaspartate; 2-Amino-3-hydroxybutanedioic Acid; three-DL-3-Hydroxyaspartic Acid; Erythro-3-hydroxy-DL-aspartic Acid
EINECS	217-463-1

Quality Control

Our 3-Hydroxyaspartic Acid is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity (typically ≥95% by HPLC), chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (three isomer)
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.