Description

4-Chloro-5-Fluoro-2-Methoxypyrimidine is a high-value halogenated pyrimidine building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research. Pharmaceutical R&D departments, agrochemical manufacturers, and advanced material scientists need this precise chemical scaffold to construct complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel nucleoside analogs and kinase inhibitors for antiviral and anticancer therapies.
• Agrochemical Research: Used in developing advanced herbicides and fungicides, leveraging its halogenated pyrimidine core for bioactivity.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the methoxypyrimidine moiety into more complex structures.
• Material Science Precursor: Potential starting material for the synthesis of organic electronic materials and liquid crystals.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	4-Chloro-5-Fluoro-2-Methoxypyrimidine
CAS No.	1801-06-5
Molecular Formula	C5H4ClFN2O
Molecular Weight	162.55 g/mol
Synonyms	2-Methoxy-4-chloro-5-fluoropyrimidine; 5-Fluoro-4-chloro-2-methoxypyrimidine; 4-Chloro-5-fluoro-2-methoxy-pyrimidine; 1801-06-5; 4-Chloro-5-fluoro-2-methoxypyrimidine; 2-Methoxypyrimidine, 4-chloro-5-fluoro-; 4-Chloro-5-fluoro-2-methoxypyrimidine (CAS 1801-06-5)
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoro-2-Methoxypyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.