Description

5-Amino-6-Chloro-2-(Trifluoromethyl)-1H-Pyrimidine-4-Thione is a high-value heterocyclic building block characterized by its unique trifluoromethyl and thione functional groups. This compound is essential for research and development in advanced organic synthesis, particularly for creating novel molecular scaffolds with enhanced biological activity and physicochemical properties. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in medicinal chemistry and agrochemical discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzymes and receptors where the trifluoromethyl group can improve metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a building block for creating specialized organic materials, such as ligands for catalysis or components in electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated pyrimidine derivatives.

Basic Information

Product Name	5-Amino-6-Chloro-2-(Trifluoromethyl)-1H-Pyrimidine-4-Thione
CAS No.	1598-59-0
Molecular Formula	C5H3ClF3N3S
Molecular Weight	229.61 g/mol
Synonyms	5-Amino-6-chloro-2-(trifluoromethyl)-4-pyrimidinethiol; 5-Amino-6-chloro-2-(trifluoromethyl)-1,4-dihydropyrimidine-4-thione; 5-Amino-6-chloro-2-(trifluoromethyl)pyrimidine-4(1H)-thione; 6-Chloro-5-amino-2-trifluoromethyl-4-mercaptopyrimidine; 4H-Pyrimidine-4-thione, 5-amino-6-chloro-1,2-dihydro-2-(trifluoromethyl)-; 1598-59-0; 5-Amino-6-chloro-2-trifluoromethyl-1H-pyrimidine-4-thione
EINECS	Contact for details

Quality Control

Our 5-Amino-6-Chloro-2-(Trifluoromethyl)-1H-Pyrimidine-4-Thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.