Description

D-2-Amino-1,1,1-Trifluoro-3-(Methyl)Butane is a high-value, non-natural amino acid derivative characterized by its trifluoromethyl group and chiral center. This compound is a critical chiral building block in modern organic synthesis, prized for introducing fluorine atoms to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated analogs of amino acids and peptides, targeting improved drug potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides where the fluorine moiety enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Proteomics & Biochemical Research: Employed in the design and study of enzyme inhibitors, receptor agonists/antagonists, and other bioactive probes.
• Material Science: A potential monomer or modifier for creating specialty polymers with unique surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity fluorinated building blocks.

Basic Information

Product Name	D-2-Amino-1,1,1-Trifluoro-3-(Methyl)Butane
CAS No.	1582-18-9
Molecular Formula	C5H10F3N
Molecular Weight	141.14 g/mol
Synonyms	(R)-2-Amino-1,1,1-trifluoro-3-methylbutane; D-2-Amino-1,1,1-trifluoro-3-methylbutane; (R)-1,1,1-Trifluoro-3-methyl-2-aminobutane; (R)-2-Amino-3-methyl-1,1,1-trifluorobutane; (R)-3-Methyl-1,1,1-trifluoro-2-aminobutane; D-2-Amino-1,1,1-trifluoro-3-methyl-butane; (R)-α-Trifluoromethylvaline amine
EINECS	Contact for details

Quality Control

Our D-2-Amino-1,1,1-Trifluoro-3-(Methyl)Butane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC, GC), to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Keep the container tightly sealed when not in use to prevent evaporation and potential moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.