Description

4-Hydroxy-2-(trifluoromethyl)pyrimidine is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl substituent, makes it indispensable for introducing fluorine atoms into complex molecules, thereby modulating their physicochemical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty chemicals, liquid crystals, and organic electronic materials requiring fluorinated aromatic systems.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry Building Block: Essential for introducing the CF3 moiety into heterocyclic compounds, altering lipophilicity, metabolic stability, and binding affinity.

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Pyrimidine
CAS No.	1546-80-1
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	2-(Trifluoromethyl)-4-pyrimidinol; 4-Hydroxy-2-trifluoromethylpyrimidine; 4-Pyrimidinol, 2-(trifluoromethyl)-; 2-Trifluoromethylpyrimidin-4-ol; 4-Hydroxy-2-(trifluoromethyl)pyrimidine; 2-Trifluoromethyl-4-hydroxypyrimidine; 4-Hydroxy-2-(trifluoromethyl)-1,3-diazine
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-2-(trifluoromethyl)pyrimidine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.