Description

4-Chloro-2-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and chloro substituents enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated pyrimidine motifs into novel compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides that leverage the biological activity of the pyrimidine core.
• Material Science Research: Serves as a building block for creating functionalized organic materials and liquid crystals.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Nucleophilic Substitution: The chloro group is readily displaced by various nucleophiles (amines, alkoxides) to create diverse 2,4-disubstituted pyrimidine libraries.
• Fluorine Chemistry Studies: A valuable compound for investigating the influence of the trifluoromethyl group on reactivity and physicochemical properties.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Pyrimidine
CAS No.	1514-96-1
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	2-(Trifluoromethyl)-4-chloropyrimidine; 4-Chloro-2-(trifluoromethyl)pyrimidine; 4-Chloro-2-trifluoromethylpyrimidine; Pyrimidine, 4-chloro-2-(trifluoromethyl)-; 1514-96-1; 4-Chloro-2-trifluoromethyl-pyrimidine; 4-Chloro-2-(trifluoromethyl)-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.