Description

Secretin, Human CAS NO 1393-25-5 is a 27-amino acid peptide hormone that plays a critical role in the regulation of gastric acid secretion and pancreatic bicarbonate output. This high-purity compound is essential for advanced research and diagnostic applications, particularly in gastrointestinal physiology and endocrinology. It is a vital reagent for pharmaceutical R&D, clinical diagnostics, and academic research focused on digestive system disorders and hormone signaling pathways.

Application

• Gastrointestinal Research: Fundamental studies on gastric acid secretion, pancreatic exocrine function, and duodenal pH regulation.
• Diagnostic Testing: Key component in the secretin stimulation test for diagnosing pancreatic exocrine insufficiency, gastrinoma (Zollinger-Ellison syndrome), and chronic pancreatitis.
• Pharmaceutical Development: Used in drug discovery programs targeting gastrointestinal disorders, including acid-related diseases and pancreatic function modulators.
• Biochemical Assays: Standard and calibrator in immunoassays (ELISA, RIA) and other analytical methods for quantifying secretin levels.
• Cell Signaling Studies: Investigation of G-protein-coupled receptor (GPCR) activation and intracellular signaling cascades mediated by the secretin receptor.
• Reference Standard: Serves as a high-purity analytical reference standard for quality control in related biopharmaceutical manufacturing.

Basic Information

Product Name	Secretin, Human CAS NO 1393-25-5
CAS No.	1393-25-5
Molecular Formula	C130H220N44O41
Molecular Weight	3055.4 g/mol
Synonyms	Secretin; Human Secretin; HGFA; SCT; Gastrointestinal Peptide Hormone; 27AA Peptide; HSDGTFTSELSRLRDSARLQRLLQGLV; SECR_HUMAN
EINECS	Contact for details

Quality Control

Our Secretin, Human is manufactured under strict quality systems to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee reproducible performance in your critical research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder desiccated. Reconstituted solutions should be aliquoted and stored at -20°C or -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Determined by suitable functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.