Description

4,6-Dichloropyrimidine is a versatile and highly reactive halogenated heterocyclic building block essential for advanced organic synthesis. Its core value lies in its two chlorine atoms at the 4 and 6 positions, which serve as excellent leaving groups for nucleophilic aromatic substitution, enabling the efficient construction of complex pyrimidine derivatives. This compound is critically needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing active ingredients and novel functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Building block for creating herbicides, fungicides, and plant growth regulators with specific biological activity.
• Material Science Research: Used in the development of organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling biomolecules or constructing chemical probes for target identification.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production of specialty chemicals.
• Academic & R&D Laboratories: Essential reagent for methodological development in organic chemistry and exploring new reaction pathways.

Basic Information

Product Name	4,6-Dichloropyrimidine
CAS No.	1193-21-1
Molecular Formula	C4H2Cl2N2
Molecular Weight	148.98 g/mol
Synonyms	4,6-Dichloro-1,3-diazine; 4,6-Dichloro-pyrimidine; Pyrimidine, 4,6-dichloro-; NSC 403697; 1,3-Diazine, 4,6-dichloro-; 4,6-DCP; 4,6-Dichloro-1,3-diazabenzene
EINECS	214-777-5

Quality Control

Our 4,6-Dichloropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports applications requiring GMP-grade starting materials and ensures compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent photodegradation. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	62 - 66 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.