Description

L-Homocitrulline is a non-proteinogenic amino acid and a structural analog of L-citrulline, distinguished by an additional methylene group in its side chain. This unique structure makes it a valuable intermediate and research chemical in the study of metabolic pathways, particularly those involving the urea cycle and nitric oxide synthase activity. It is primarily utilized by research institutions, pharmaceutical developers, and manufacturers of high-purity biochemicals for applications in metabolic research, diagnostic reagent formulation, and as a building block for peptide synthesis.

Application

• Biochemical Research & Development: Used as a key intermediate and reference standard in metabolic studies, particularly for investigating the urea cycle, nitric oxide (NO) pathways, and amino acid metabolism.
• Pharmaceutical Intermediates: Serves as a chiral building block in the synthesis of novel peptides and pharmaceutical compounds targeting cardiovascular and metabolic disorders.
• Diagnostic Reagents: Employed in the formulation of enzymatic assay kits and calibrators for clinical diagnostics related to amino acid disorders and renal function.
• Nutritional Science Studies: Investigated for its potential role and interactions in nutritional supplements, often in comparative studies with L-citrulline and L-arginine.
• Cell Culture & Microbiology: Used as a specialized component in defined cell culture media for specific microbial or mammalian cell line research.
• Standards & Calibration: Provides a high-purity standard for analytical methods such as HPLC, LC-MS, and amino acid analysis in quality control laboratories.

Basic Information

Product Name	L-Homocitrulline
CAS No.	1190-49-4
Molecular Formula	C7H15N3O3
Molecular Weight	189.21 g/mol
Synonyms	L-2-Amino-6-(carbamoylamino)hexanoic acid; (S)-2-Amino-6-ureidohexanoic acid; N5-(Aminocarbonyl)-L-ornithine; L-N5-Carbamoylornithine; Homo-L-citrulline; (S)-Homocitrulline; L-Ornithine, N5-carbamoyl-
EINECS	214-737-8

Quality Control

Our L-Homocitrulline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for research and industrial use. A Certificate of Analysis (COA) detailing specific results for assay, chiral purity, and impurities is provided with every shipment to guarantee reliable and traceable quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Specific Rotation [α]D20	+15.0° to +18.0° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.