Description

(-)-2-[(S)-1-O,2-o-Dioctadecyl-D-Glycero-3-Phospho]Ethylamine is a high-purity, synthetic phospholipid derivative, specifically a phosphoethanolamine with defined stereochemistry and long-chain alkyl groups. This compound is critical for creating stable, functional lipid bilayers and vesicles with tailored surface properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, well-characterized lipid components for advanced drug delivery systems, diagnostic assays, and membrane biophysics studies.

Application

• Liposome and Nanoparticle Formulation: A key structural lipid for creating stable, long-circulating liposomes and lipid nanoparticles (LNPs) for targeted drug and nucleic acid (e.g., mRNA, siRNA) delivery.
• Membrane Protein Research: Used in the reconstitution and stabilization of membrane proteins for structural and functional studies, benefiting from its defined chemical structure.
• Biomimetic Membrane Models: Serves as a fundamental building block for constructing supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) to study cell membrane mechanics and interactions.
• Diagnostic Reagent Development: Employed in the surface functionalization of diagnostic particles and sensors to improve specificity and reduce non-specific binding.
• Gene Therapy Vectors: A component in non-viral vector formulations designed for efficient cellular uptake and endosomal escape of genetic material.
• Cosmetic Actives Carrier: Utilized in high-end cosmetic formulations to encapsulate and enhance the delivery of active ingredients into the skin.

Basic Information

Product Name	(-)-2-[(S)-1-O,2-o-Dioctadecyl-D-Glycero-3-Phospho]Ethylamine
CAS No.	1188-85-8
Molecular Formula	C41H84NO6P
Molecular Weight	718.09 g/mol
Synonyms	1,2-Di-O-octadecyl-sn-glycero-3-phosphoethanolamine; DOPE (C18:0); 1,2-Distearyl-sn-glycero-3-phosphoethanolamine; DSPE (C18:0); DODG-PE; 1,2-Di-O-octadecyl-rac-glycero-3-phosphoethanolamine (racemic mixture); 3-Phosphoethanolamine, 1,2-di-O-octadecyl-sn-glycerol ester; Phospholipid PE(18:0/18:0)
EINECS	Contact for details

Quality Control

Our (-)-2-[(S)-1-O,2-o-Dioctadecyl-D-Glycero-3-Phospho]Ethylamine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, TLC for lipid profile, and NMR for structural verification. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents, residual moisture, and heavy metals, ensuring compliance with research and cGMP-grade material expectations for critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.